Distal renal tubular acidosis (dRTA) and bone histomorphometry

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Renal Tubular Acidosis Type 1: Distal Renal Tubular Acidosis (dRTA) in Children

Renal tubular acidosis type 1, also called distal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciuria, hypocitraturia, and low urinary NH4. Its etiology is variable and includes sporadic, hereditary, and acquired forms. It should be differentiated from other forms of RTA and other causes of metabolic acidosis. Long-term alkali therapy is th...

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Renal Tubular Acidosis Type 1: Distal Renal Tubular Acidosis (dRTA) in Children

Renal tubular acidosis type 1, also called distal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciuria, hypocitraturia, and low urinary NH4. Its etiology is variable and includes sporadic, hereditary, and acquired forms. It should be differentiated from other forms of RTA and other causes of metabolic acidosis. Long-term alkali therapy is th...

متن کامل

Renal Tubular Acidosis Type 1: Distal Renal Tubular Acidosis (dRTA) in Children

Renal tubular acidosis type 1, also called distal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciuria, hypocitraturia, and low urinary NH4. Its etiology is variable and includes sporadic, hereditary, and acquired forms. It should be differentiated from other forms of RTA and other causes of metabolic acidosis. Long-term alkali therapy is th...

متن کامل

Renal Tubular Acidosis Type 1: Distal Renal Tubular Acidosis (dRTA) in Children

Renal tubular acidosis type 1, also called distal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciuria, hypocitraturia, and low urinary NH4. Its etiology is variable and includes sporadic, hereditary, and acquired forms. It should be differentiated from other forms of RTA and other causes of metabolic acidosis. Long-term alkali therapy is th...

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Defective kidney anion-exchanger 1 (AE1, Band 3) trafficking in dominant distal renal tubular acidosis (dRTA).

dRTA (distal renal tubular acidosis) results from the failure of the a-intercalated cells in the distal tubule of the nephron to acidify the urine. A truncated form of AE1 (anion-exchanger 1; Band 3), kAE1 (kidney isoform of AE1), is located in the basolateral membrane of the intercalated cell. Mutations in the AE1 gene cause autosomal dominant and recessive forms of dRTA. All the dominant dRTA...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2011

ISSN: 0085-2538

DOI: 10.1038/ki.2011.162